Three people are dead after tornadoes struck Oklahoma and about 40 million Americans are at risk of severe weather Thursday, forecasters say, marking the second consecutive day tornado and storm watches will be in effect for the central U.S.

A tornado watch was issued Thursday afternoon for portions of the upper Midwest, including the Chicago metro area. A tornado watch means weather conditions are favorable for tornadoes to form. 

The Plains region has been the focal point for extreme weather throughout the week. Wednesday night, a severe storm spawned  tornadoes in central Oklahoma, which also led to several injuries in addition to the deaths.

For some in the central U.S. who aren’t threatened by Thursday’s severe weather , the risk remains for flooding, fast-developing wildfires and even heavy snow.

In the East and South, residents will enjoy unseasonably warm temperatures. Flooding will be a concern in the East, red flag warnings will remain in the West, and precipitation should continue in the North.

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Here’s what to know about the national weather forecast for Thursday:

3 dead in Oklahoma after tornado

The small town of Cole, Oklahoma – home to about 600 people – was hit hard by a tornado, McClain County Deputy Sheriff Scott Gibbon told NBC’s “Today.”

Officials responded to multiple homes with people trapped inside, he said. One person died on the scene, and another died of a “heart-related issue” while being transported to a hospital, he said.