In the eight years since Hillary Clinton failed to win the American presidency, the work force for the first time grew to include more college-educated women than college-educated men. The #MeToo movement exposed sexual harassment and toppled powerful men. The Supreme Court overturned the federal right to abortion.

Will any — or all — of it make a difference for Vice President Kamala Harris?

Ms. Harris seems almost certain to become the Democratic Party’s presidential nominee after President Biden’s decision not to seek re-election. As such, she faces, fairly or not, some of the same electability questions that Mrs. Clinton confronted in a nation that, unlike many of its peers around the globe, has yet to pick a woman as its leader.

A presidential contest pitting Ms. Harris against former President Donald J. Trump would represent a rematch of sorts: Mr. Trump would again have to run against a woman who held a top administration position and served in the Senate. He defeated Mrs. Clinton in 2016 in spite of her winning the popular vote by a wide margin.

But the dynamics would be unquestionably different. Ms. Harris has neither the political legacy nor the baggage of Mrs. Clinton. Mr. Trump, having served a turbulent term in office, is now a known quantity. Ms. Harris is Black and of South Asian descent.

And the country is not the same as it was eight long years ago.

“Women are angrier, and that could be motivating,” said Karen Crowley, 64, an independent voter and retired nurse in Concord, N.H., who would not vote for Mr. Trump, did not feel like she could support Mr. Biden and now planned to back Ms. Harris.

Among the motivations Ms. Crowley cited were the demise of Roe v. Wade and comments and actions by Mr. Trump that many women see as sexist and misogynistic. “A woman president might be more possible now,” she said.