As new coronavirus variants gain traction across the United States, summer travelers are facing a familiar and tiresome question: How will the ever-mutating virus affect travel plans?

In light of updated guidelines from the Centers for Disease Control and Prevention, the answers may be slightly different from those in previous years.

Here’s what to know about traveling this summer if you’re worried about — or think you might have — Covid-19.

Recent C.D.C. data show that Covid infections are rising or most likely rising in more than 40 states. Hospitalization rates and deaths, while low compared with the peaks seen in previous years, are also on the rise.

The uptick is tied to a handful of variants — named KP.2, KP.3 and LB.1 — that now account for a majority of new cases.

At the same time, record numbers of people are expected to travel over July 4 and the holiday weekend.