The United States has seen five cases of malaria spread by mosquitos in the last two months, — the first time there’s been local spread in 20 years — prompting officials to issue a public health alert warning doctors, public health authorities, and the public about the risk Monday.

Four cases were identified in southwest Florida and one in southern Texas, the Centers for Disease Control and Prevention said. The five cases are the first in 20 years to be caught locally in the United States.

“Malaria is a medical emergency and should be treated accordingly,” the CDC said. “Patients suspected of having malaria should be urgently evaluated in a facility that is able to provide rapid diagnosis and treatment, within 24 hours of presentation.”

Malaria is a serious disease transmitted through the bite of an infective female anopheline mosquito, according to the CDC. Although malaria can be fatal, the CDC said illness and death from the disease can usually be prevented.

There is no evidence the five cases in the two states are related, the CDC said. The four cases in Florida were identified in Sarasota County and the Florida Department of Health issued a statewide mosquito-borne illness advisory Monday.

Only one case was identified in a Texas resident who spent time working outdoors in Cameron County, according to the Texas Department of State Health Services.

Both departments in Florida and Texas said public health authorities are monitoring local mosquito populations and surveilling their regions for other cases. The Florida Department of Health said it was also working to control the mosquito population in Sarasota County.