Those messages — some to her husband, from whom she is separated — seem like a slight misstep; in a play that otherwise avoids exposition like a bad smell (we otherwise know only what the women tell one another) they are too on the nose. Still, they serve a purpose, besides being harrowing, in that they propel the play into its final third, in which the discussion of desire gives way to an opportunity to enact it. But if you think you see where that’s going, you will be both right and wrong; Baker’s structures are so strong and yet open that, within them, anything or its opposite may happen at any moment.

Maintaining that tension between plot and anti-plot, while using it to deepen our engagement in a story that seems random but isn’t, requires the most exquisite directorial care. “Infinite Life” (a co-production with Britain’s National Theater) gets that and more from James Macdonald, who has notably staged plays by Baker in London and by the British playwright Caryl Churchill here in New York. Indeed, “Infinite Life” most closely reminded me of Churchill’s great “Escaped Alone,” in which four women sit in a garden chatting into the apocalypse.

But Macdonald understands that Baker’s practice is not the same as Churchill’s. The women here (if not the man) are fully, almost floridly conceived, not just elements slotted into a formal conceit. Baker’s is a rich minimalism, as if the characters in a Tennessee Williams melodrama found themselves in an Albee one-act. Despite the difficulty of realizing that, the cast of six New York regulars is excellent: as good as I’ve ever seen any of them, and in the case of Nielsen, so wonderfully restrained, even better. For all the detailed behavior that shows up at the surface — the various ways the women sip from their water bottles, the shuffling or striding or creeping to their chaises — you always sense the greater weight of whatever lies beneath.

That the characters also live in a world of ideas gives the play its intellectual heft and complex texture, both light and profound. The contrast is beautifully maintained by the physical production, in which even the breeze-block wall framing the patio, by the design studio dots, is on point: a tracery of concrete and air. The women’s stretchy sweats, batik pajamas and lightweight cover-ups, by Ásta Bennie Hostetter, signify comfort but also the need for it. Birdsong and road noise are the poles of Bray Poor’s bifurcated sound world. And in Isabella Byrd’s lighting design, the minute we get used to the nearly invisible night, with just a cellphone to see by, we are snapped into the harsh May sun of the following midday.

They are all expressions of Baker’s refusal to reduce the world to a unitary lesson; “Infinite Life” offers moral philosophy but no moral. (If pain “means anything at all,” Sofi says, “then I don’t know if I can bear it.”) Illness, after all, is no metaphor. It has no purpose, is no judgment, cannot be done right or wrong; it is only itself, incomparable (though some of the characters compete over whose wretchedness is worse) and uninterpretable.

Which does not mean it is useless to think about. (When first announced for 2021, the play was called “On the Uses of Pain for Life.”) Understanding suffering, like understanding desire, may help us when we face it, or when others do, and with any luck afterward. Which, by the way, is what “Daniel Deronda,” past page 152, is about — and “Infinite Life” is always.

Infinite Life
Through Oct. 8 at the Linda Gross Theater, Manhattan; atlantictheater.org. Running time: 1 hour 45 minutes.