At the close in Tokyo, the Nikkei 225 lost 0.19%.
The best performers of the session on the Nikkei 225 were Eisai Co., Ltd. (T:4523), which rose 19.35% or 1500.0 points to trade at 9251.0 at the close. Meanwhile, Kawasaki Kisen Kaisha, Ltd. (T:9107) added 4.92% or 160.0 points to end at 3415.0 and Daiichi Sankyo Co., Ltd. (T:4568) was up 4.92% or 116.5 points to 2483.0 in late trade.
The worst performers of the session were Sumitomo Metal Mining Co., Ltd. (T:5713), which fell 4.07% or 198.0 points to trade at 4665.0 at the close. Oji Holdings Corp. (T:3861) declined 3.12% or 21.0 points to end at 653.0 and Daikin Industries, Ltd. (T:6367) was down 3.12% or 660.0 points to 20520.0.
Rising stocks outnumbered declining ones on the Tokyo Stock Exchange by 2239 to 1240 and 252 ended unchanged.
Shares in Kawasaki Kisen Kaisha, Ltd. (T:9107) rose to 5-year highs; up 4.92% or 160.0 to 3415.0.
The Nikkei Volatility, which measures the implied volatility of Nikkei 225 options, was unchanged 0% to 20.15.
Crude oil for July delivery was down 0.61% or 0.42 to $68.81 a barrel. Elsewhere in commodities trading, Brent oil for delivery in August fell 0.64% or 0.46 to hit $71.03 a barrel, while the August Gold Futures contract fell 0.07% or 1.35 to trade at $1897.45 a troy ounce.
USD/JPY was up 0.22% to 109.48, while EUR/JPY rose 0.07% to 133.24.
The US Dollar Index Futures was up 0.18% at 90.105.