Greenberg: Duke showed championship DNA vs. Michigan State (0:58)

Seth Greenberg and Stephen A. Smith react to Duke advancing to the Sweet 16 after a win over Michigan State. (0:58)

The first full day of the NCAA tournament featured eight games decided by single digits, six lower-seeded teams advancing, four double-digit seeds winning, three overtime games and one of the biggest upsets in NCAA tournament history.

And the weekend didn’t slow down from there. The Sweet 16, which begins Thursday in San Antonio and San Francisco, features a 15-seed for just the third time in tournament history, as well as four double-digit seeds. Three 1-seeds are still dancing, but one needed overtime to advance and another had to overcome a double-digit deficit in the second round.

So yes, the Madness has lived up to its name.

What will the next two rounds of the NCAA tournament look like? More upsets or top seeds advancing to New Orleans? I reached out to coaches who have faced the four regional favorites to find out which potential opponent poses the biggest challenge — and much more — to get you prepared for the Sweet 16.