Its members refer to it as the Axis of Resistance.

It is the network of Iran-backed groups across the Middle East dedicated to reducing U.S. influence in the region and ultimately eliminating the state of Israel. The network’s name is a play on former President George W. Bush’s 2002 claim that Iran, Iraq and North Korea made up an Axis of Evil.

The Axis of Resistance includes Hamas, Hezbollah, the Houthis and other groups, and both its strategy and its tactics have long been radical. The official slogan of the Houthis — the Yemen-based group that has attacked commercial ships in the Red Sea — includes “death to America, death to Israel, a curse upon the Jews,” for example.

Nonetheless, the conflict between the Axis and its enemies had remained limited for years. Even though Iran funds and supports the Axis, other countries have often treated its member groups as distinct from Iran. Attacks by Hamas or Hezbollah usually did not lead to reprisals against Iran.

The events of the past few months threaten to change this dynamic. In today’s newsletter, I’ll explain why.

The main turning point, of course, was Oct. 7. Hamas conducted the deadliest terrorist attack in Israel’s history and said it would repeat the attacks until Israel was destroyed. Israel has responded by vowing to destroy Hamas, and its war in Gaza has flattened neighborhoods and killed tens of thousands of Palestinians. In solidarity with Hamas, Hezbollah has fired missiles into Israel, while the Houthis have disrupted global commerce.

Initially, Iran remained somewhat removed from the fighting. Although its leaders praised the Oct. 7 attack as a step toward the end of Israel, they privately said they did not help plan the attack — and U.S. officials agree they did not. All three countries took steps to avoid a wider war.