WASHINGTON—Judge Ketanji Brown Jackson faced a second full day of questioning from senators on Wednesday, with some Republicans set to further press the Supreme Court nominee over her sentences for convicted criminals, while Democrats maintain hopes for a bipartisan confirmation vote.

Judiciary Committee Chairman Dick Durbin (D., Ill.) opened the hearing with comments defending Judge Jackson’s record on crime, citing her support from the Fraternal Order of Police and the International Association of Chiefs of Police.