“Black Friday epitomises an obsession with overconsumption that is not consistent with a liveable planet,” the group said.
“Amazon and companies like it have capitalised on our desire for convenience and stoked rampant consumerism at the expense of the natural world,” it said.
A Reuters reporter at an Amazon depot at Tilbury docks in eastern England said protesters had blocked the entrance.
Banners read: “Black Friday exploits people and planet”, “Amazon crime” and “Infinite growth, finite planet.”
Extinction Rebellion said blockades were also being held at Amazon depots in cities including Manchester, Newcastle and Bristol as well as at depots in Germany and the Netherlands.
Amazon, which brought the Black Friday discount day to Britain in 2010, had no immediate comment.